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Updated: Jan 16, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
The association of mild cognitive impairment with outpatient visits for hypertension
Mellanie V Springer1,2, Yi Chen3,4, Slim Benloucif5
1Department of Neurology and Stroke Program, University of Michigan, Ann Arbor, Michigan, USA.
Insights
Older adults with mild cognitive impairment (MCI) and hypertension attend fewer outpatient visits for hypertension management compared to those without cognitive impairment. This highlights a need for interventions to improve care engagement.
Area of Science:
- Gerontology
- Neurology
- Public Health
Background:
- Hypertension management is crucial for preventing mild cognitive impairment (MCI) progression to dementia.
- The engagement of older adults with hypertension and MCI in outpatient care is not well understood.
Purpose of the Study:
- To investigate the association between cognitive status (MCI vs. no cognitive impairment) and the frequency of outpatient hypertension management visits among older adults.
Main Methods:
- Analysis of data from older adults with hypertension in Rush Alzheimer's Disease Center (RADC) cohorts (2011-2019).
- Utilized repeated measures negative binomial regression to assess the relationship between cognitive status and annual outpatient clinic visits for hypertension evaluation and management (E&M).
Main Results:
- Older adults with MCI (n=1013 person-years) had 8% fewer annual outpatient visits for hypertension compared to those with no cognitive impairment (NCI) (n=4373 person-years).
- The relative incidence ratio (RIR) for outpatient visits was 0.92 (p < 0.01) for individuals with MCI.
Conclusions:
- Older adults with MCI may be less likely to engage in recommended outpatient hypertension management.
- Interventions are needed to increase engagement in outpatient care for hypertension among individuals with MCI.
Introduction:
Hypertension management is critically important to reduce the risk of conversion of mild cognitive impairment (MCI) to dementia. The degree to which older adults with hypertension and MCI engage in outpatient ambulatory care for hypertension management is unclear.
Methods:
Among older adults with hypertension in the Rush Alzheimer's Disease Center (RADC) cohorts (2011 to 2019), we used repeated measures negative binomial regression to evaluate the association between cognitive status (MCI vs no cognitive impairment [NCI]) and number of annual outpatient clinic visits for hypertension evaluation and management (E&M) (primary outcome).
Results:
MCI (n = 1013 person-years) was associated with 8% fewer outpatient visits for hypertension versus older adults with NCI (n = 4373 person-years) (relative incidence ratio [RIR] 0.92, p < 0.01).
Discussion:
Despite the known adverse cognitive effects of hypertension, older adults with MCI may be less likely to engage in outpatient hypertension management.
Highlights:
Fewer outpatient hypertension visits among adults with MCI versus NCI. Fewer primary care hypertension visits among adults with MCI versus without MCI. Need for interventions to engage adults with hypertension and MCI in outpatient care.
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