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Prevalence and Risk Factors for Venous Thromboembolism in People With Inherited Bleeding Disorders: An ATHNdataset
Shreya Agarwal1, Joseph R Stanek2,3, Jianzhong Hu4
1Division of Hematology, Department of Pediatrics, University of California, San Francisco, California, USA.
American Journal of Hematology
|September 27, 2025
Summary
Individuals with inherited bleeding disorders are not protected from venous thromboembolism (VTE). Risk factors for VTE include Black race, central venous lines, and cardiac conditions, highlighting the need for vigilance in this population.
Area of Science:
- Hematology
- Thrombosis
- Genetics
Background:
- It is often presumed that individuals with inherited bleeding disorders (IBDs) are protected against venous thromboembolism (VTE).
- However, data on VTE rates and risk factors within this specific population are limited.
- This study addresses the lack of evidence regarding VTE risk in individuals with IBDs.
Purpose of the Study:
- To determine the incidence rates of VTE in a cohort of individuals with IBDs.
- To identify specific risk factors associated with VTE development in this population.
- To challenge the assumption of VTE protection in individuals with IBDs.
Main Methods:
- Utilized the American Thrombosis and Hemostasis Network (ATHN) dataset.
- Included individuals with IBDs and a documented VTE diagnosis.
- Employed descriptive statistics and logistic regression to analyze VTE rates and risk factors.
Main Results:
- Identified 388 new VTE events (0.8%) among 49,151 individuals with IBDs.
- VTE rates varied significantly by disorder, with prothrombin deficiency at 19% and hemophilia A/B at 0.4%.
- Identified risk factors for VTE included Black race, central venous line (CVL) use, and cardiac comorbidities.
Conclusions:
- The findings demonstrate that individuals with IBDs are not inherently protected against VTE.
- Cardiac comorbidity and CVL presence significantly increase VTE risk in this cohort.
- Further research and clinical vigilance are warranted for VTE prevention in individuals with IBDs.
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