Related Experiment Video
Updated: Jan 16, 2026

Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle
Published on: August 30, 2021
Contraceptive-induced amenorrhea: An exploratory study of perceptions among a reproductive-age urban Southern
Irene Masini1, Emily Frisch2, Rana Andary1
1School of Medicine, University of California, Irvine, United States.
Objectives:
To evaluate the preferences for and knowledge of contraceptive-induced amenorrhea among a reproductive age predominantly Hispanic community in Southern California.
Methods:
This cross-sectional study recruited English and Spanish speaking reproductively capable participants from three outpatient clinics associated with a large academic hospital. A validated survey assessed preferences and knowledge surrounding contraceptive-induced amenorrhea. Descriptive statistics, bivariate analyses using chi-squared tests, and multivariate regression were performed to evaluate the association between demographic variables and the desire for contraceptive-induced amenorrhea, as well as its perceived safety.
Results:
Of 209 respondents (response rate: 78.9 %), 66.5 % were Hispanic and 48.8 % identified as Christian. A majority of participants (56.5 %) would not consider a contraceptive method that would induce amenorrhea. Furthermore, a majority of participants (64.1 %) believed that contraceptive-induced amenorrhea is harmful. Belief of harm due to contraceptive-induced amenorrhea was associated with avoiding contraception that could induce amenorrhea (p < 0.001). However, participants who were discontent with menstruation statistically preferred contraceptive-induced amenorrhea (p < 0.01). No significant association was found between race and preference for contraceptive-induced amenorrhea (p = 0.89) or understanding of its safety (p = 0.34).
Conclusions:
The majority of our sample would not prefer contraceptive-induced amenorrhea and feared that amenorrhea would be harmful. Given the perceived harm of contraceptive induced amenorrhea may limit the use of highly effective methods for all races, educational initiatives aimed at reviewing safety may allow for more informed patient decision-making.
Related Concept Videos
Menopause
Birth Control Methods
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of...
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...

