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Updated: Jan 16, 2026

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies
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Reference-guided assembly of metagenomes with MetaCompass

Tu Luan1, Victoria P Cepeda-Espinoza1, Bo Liu1

  • 1Department of Computer Science, University of Maryland, College Park, MD 20742, USA; Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA.

Cell Reports Methods
|September 27, 2025
PubMed
Summary

This study introduces reference-guided assembly for metagenomics, improving gene and genome reconstruction from microbial communities. This method complements existing de novo approaches, especially as more reference genomes become available.

Keywords:
CP: geneticsCP: microbiologycomparative assemblymetagenome assemblymetagenomicsmicrobiomereference-guided assembly

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