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A foundational architecture for AI agents in healthcare
Fei Liu1, Yue Niu2, Qihua Zhang3
1Institute for AI in Medicine and Faculty of Medicine, Macau University of Science and Technology, Macau, China; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Eye Health, Institute for Advanced Study on Eye Health and Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China.
None:
Medical AI agents represent a transformative paradigm in healthcare, distinguished from traditional AI by their autonomy, adaptability, and ability to manage complex tasks. This review introduces a conceptual framework for these agents built on four core components: planning, action, reflection, and memory. We examine the framework's application across key clinical domains, from enhancing diagnostic accuracy and personalizing treatment to guiding robotic surgery and enabling real-time patient monitoring. The review critically analyzes implementation challenges, including technical integration, clinician adoption, regulatory adaptation, and ethical considerations like data privacy and algorithmic bias. Future directions are explored, including the shift toward proactive, multi-agent collaborative systems and the visionary AI Agent Hospital concept. While these agents hold immense potential to revolutionize healthcare delivery by improving efficiency and patient outcomes, their successful and equitable integration hinges on navigating these profound technical, ethical, and regulatory hurdles.
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