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Published on: May 25, 2020
A Comparison of 24-2C Swedish Interactive Thresholding Algorithm (SITA) Faster and 10-2 SITA Standard for Detecting
Euido Nishijima1, Ryosuke Ito1, Kei Sano1
1Department of Ophthalmology, The Jikei University School of Medicine, Nishi-Shimbashi, Tokyo, Japan.
Purpose:
To compare the diagnostic accuracy of 24-2C Swedish Interactive Thresholding Algorithm (SITA) Faster and 10-2 SITA Standard in detecting macular damage in mild-stage glaucoma.
Design:
Multicenter diagnostic accuracy study based on prospectively collected data.
Participants:
In total, 108 eyes from 108 patients with mild-stage glaucoma (normal-tension glaucoma, 58; high-tension glaucoma, 50) and 52 eyes from 52 healthy controls at the Jikei University School of Medicine and Tajimi Iwase Eye Clinic.
Methods:
Participants underwent 24-2C SITA Faster and 10-2 SITA Standard visual field testing on the same day, in randomized order. OCT with ganglion cell analysis identified macular damage. McNemar test and noninferiority analysis (10% margin) compared detection accuracy. Test durations were compared using pairwise t-tests.
Main Outcome Measures:
Sensitivity and specificity of 24-2C SITA Faster and 10-2 SITA Standard for detecting macular damage and test duration.
Results:
For overall macular damage, 24-2C SITA Faster demonstrated sensitivity or specificity of 0.64/0.93 (total deviation [TD]) and 0.67/0.93 (pattern deviation [PD]), while 10-2 SITA Standard demonstrated 0.69/0.94 (TD) and 0.77/0.93 (PD). McNemar test revealed no significant difference, and 24-2C SITA Faster was noninferior within the 10% margin. Subanalysis with a strict 5% margin, revealed that 10-2 SITA Standard was superior to 24-2C SITA Faster when using PD plot for all parameters. The mean test duration was significantly shorter for 24-2C SITA Faster (158.5 seconds) than for 10-2 SITA Standard (330.0 seconds; P < 0.001).
Conclusions:
24-2C SITA Faster is a noninferior and more time-efficient alternative to 10-2 SITA Standard for detecting macular damage in mild-stage glaucoma; however, 10-2 SITA Standard may be considered superior for detecting subtle macular defects using PD.
Financial Disclosure(S):
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
