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[Research progress in the role of STMN1 in tumor]

Xingxing Ma1, Muzi Li2, La Chen2

  • 1First School of Clinical Medicine, Anhui Medical University, Hefei 230032. 2412852241@qq.com.

Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences
|September 27, 2025
PubMed

Insights

Stathmin 1 (STMN1) is a protein that drives cancer progression and resistance to therapy. Targeting STMN1 may offer a new strategy for cancer treatment and improve patient outcomes.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Stathmin 1 (STMN1) is a key microtubule-associated protein.
  • STMN1 regulates cytoskeletal dynamics and cell cycle.
  • Elevated STMN1 expression is observed in various cancers.

Purpose of the Study:

  • To investigate the role of STMN1 in cancer progression.
  • To explore STMN1's involvement in tumor-associated pathways.
  • To evaluate STMN1 as a potential biomarker and therapeutic target.

Main Methods:

  • Literature review of STMN1 function and clinical relevance.
  • Analysis of STMN1's role in proliferation, invasion, metastasis, and angiogenesis.
  • Examination of STMN1's impact on immune cell function and drug resistance.

Main Results:

  • STMN1 promotes cancer cell proliferation, invasion, metastasis, and angiogenesis.
  • STMN1 influences antitumor immunity by modulating immune cells.
  • High STMN1 expression correlates with drug resistance and poor prognosis.

Conclusions:

  • STMN1 is a significant driver of malignant tumor progression.
  • STMN1 represents a promising biomarker for predicting patient prognosis.
  • Targeting STMN1 holds potential for novel cancer therapies.
Keywords:
ferroptosismicrotubulestathmin 1tumortumor drug resistancetumor immunity

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