Related Experiment Video

Updated: Jan 16, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

440

Splenic stiffness measurement by transient elastography for predicting varices in children with portal hypertension

Janvi Sirwani1, Samarendra Mahapatro1, Aditi Kumar1

  • 1Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Journal of Pediatric Gastroenterology and Nutrition
|September 28, 2025
PubMed

Insights

Spleen-dedicated vibration-controlled transient elastography (VCTE) accurately predicts esophageal varices in children with portal hypertension. This non-invasive method aids in managing and screening for this condition.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Medical Imaging

Background:

  • Portal hypertension in children can lead to serious complications like esophageal varices.
  • Accurate non-invasive methods are needed for early detection and risk stratification.

Purpose of the Study:

  • To assess the diagnostic accuracy of splenic stiffness measurement (SSM) using spleen-dedicated vibration-controlled transient elastography (VCTE).
  • To predict the presence of varices and varices needing treatment (VNT) in children with clinically evident portal hypertension (CEPH).

Main Methods:

  • A prospective cross-sectional study included children aged 6 months to 14 years with CEPH.
  • SSM was measured using a spleen-specific VCTE probe (100 Hz).
  • Esophagogastroduodenoscopy (EGD) was used for variceal detection and risk stratification.

Main Results:

  • SSM showed good accuracy in predicting varices (AUC: 0.86) and VNT (AUC: 0.838).
  • Higher SSM values correlated with the presence and severity of varices (p < 0.001).
  • Specific thresholds for SSM demonstrated significant sensitivity and specificity for varices and VNT.

Conclusions:

  • Spleen-dedicated VCTE-measured SSM is a reasonably accurate tool for predicting varices and VNT in children with CEPH.
  • Integrating SSM into clinical practice can support the screening and management of pediatric portal hypertension.
Abstract

Keywords:
Fibro scanSSMdiagnostic tests

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