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Related Concept Videos

CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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Updated: Jan 6, 2026

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Aptamer-based PSA biosensing technology: From nanomaterials to CRISPR-diagnostics technology.

Xuanyu Guo1, Jindong Zhang1, Kun Han1

  • 1Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Talanta
|September 28, 2025
PubMed
Summary

Advanced aptamer biosensors show promise for early prostate cancer detection. Innovations in nanomaterials and CRISPR-Dx technology enhance sensitivity and reliability for point-of-care testing.

Keywords:
Aptamer-based biosensorsCRISPR-DxDual-modal detectionNanomaterialsProstate cancerProstate-specific antigen (PSA)

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Area of Science:

  • Biomedical Engineering
  • Molecular Diagnostics
  • Cancer Biomarkers

Background:

  • Prostate cancer is a major cause of male mortality, necessitating early detection.
  • Prostate-specific antigen (PSA) is a critical biomarker for prostate cancer diagnosis.
  • Existing PSA detection methods (ELISA, CLIA) have limitations in sample preparation and assay time.

Purpose of the Study:

  • To review recent advancements in aptamer-based biosensors for PSA detection (2019-2025).
  • To focus on nanomaterial innovation, CRISPR-Dx integration, and dual-modal sensing.
  • To assess current technologies' strengths/limitations and suggest future directions.

Main Methods:

  • Review of recent literature on aptamer-based PSA biosensors.
  • Analysis of nanomaterial applications in biosensing.
  • Evaluation of CRISPR-Dx and dual-modal detection strategies.

Main Results:

  • Aptamer biosensors offer high affinity and specificity for PSA detection.
  • Novel nanomaterials and dual-modal technologies improve sensitivity and reliability.
  • CRISPR-Dx integration enhances accuracy in complex biological samples.

Conclusions:

  • Innovations in aptamer biosensors are paving the way for improved PSA detection.
  • These advancements support the development of portable point-of-care testing (POCT) devices.
  • Future research should focus on enhancing efficiency and clinical utility for early screening and personalized treatment.