Thermal analysis of biological tissue under pulsed laser irradiation accounting for temperature-dependent properties

This study proposes an analytical approach to examine the thermal response of biological tissues with temperature-dependent properties subjected to pulsed laser irradiation. A bio-heat conduction model incorporating variable thermo-physical parameters was developed based on the dual-phase lag (DPL) heat conduction theory. Using the Laplace transform technique, an exact solution of the governing equation was derived in the transform domain, while numerical solutions in the time domain were obtained through the Stehfest inversion algorithm. The temperature distributions in typical biological tissues under pulsed laser irradiation were systematically computed, and the influences of temperature-dependent thermal parameters, blood perfusion rate, and metabolic heat generation were quantitatively evaluated under distinct heating mechanisms governed by phase lag times. The results reveal significant variations in thermal response due to temperature dependence, offering valuable insights for optimizing thermal therapy protocols.