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Updated: Jan 16, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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Construction of a modified Arrhenius equation for predicting drug nitrosation in solid dosage form

Yuki Takegawa1, Misaki Sugimoto2, Hiromasa Uchiyama3

  • 1Department of Formulation Design and Pharmaceutical Technology, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan; Analytical Chemistry Department, Sawai Pharmaceutical Co., Ltd. 5-2-30, Miyahara, Yodogawa-ku, Osaka 532-0003, Japan.

International Journal of Pharmaceutics
|September 28, 2025
PubMed
Abstract

Keywords:
Alkaline excipientArrhenius equationChemical stabilityDesloratadineNDSRINitrosamineSolid state

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