The age- and sex-specific association between metabolic body composition and lung function: a cross-sectional study
Wen-Cheng Li1, Yi-Hsuan Chen2, Chia-Wei Lu3
1Department of Family Medicine, Chang-Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Endocrine Journal
|September 28, 2025
Summary
Metabolically unhealthy obesity (MUO) and metabolic obesity with normal weight (MONW) are linked to a higher risk of restrictive lung disease (RLD). These conditions may help identify individuals with early-stage RLD during health checkups.
Area of Science:
- Pulmonology
- Metabolic Health
- Body Composition Analysis
Background:
- Metabolic body composition is a potential predictor of lung function.
- Understanding the link between metabolic health and pulmonary function is crucial for preventative care.
Purpose of the Study:
- To investigate the association between metabolic body composition and lung function.
- To identify metabolic risk factors for restrictive lung disease (RLD).
Main Methods:
- Cross-sectional observational study of adults aged ≥18 years.
- Analysis of data from annual health examinations (2013-2016).
- Evaluation of lung function and metabolic body composition, adjusting for confounding factors.
Main Results:
- Metabolically unhealthy obesity (MUO) and metabolic obesity with normal weight (MONW) were associated with poorer lung function.
- Higher prevalence of MUO and MONW observed in males compared to females.
- Prevalence of restrictive lung disease (RLD) was significantly higher in men.
Conclusions:
- MUO and MONW are independent risk factors for RLD.
- These metabolic conditions may serve as screening markers for preclinical RLD.
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