Related Experiment Video

Updated: Jan 16, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

24.9K

Misclassification of TP53 germline variants: implications for survival analysis in AML transplant studies

Léa Rodriguez1, François Delhommeau1,2, Thierry Soussi3,4

  • 1Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, UMRS_938 Hematopoietic and Leukemic Development, AP-HP, SIRIC CURAMUS, Paris, France.

Leukemia
|September 28, 2025
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

10.0K
Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues
07:17

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

1.8K

Related Experiment Videos

Last Updated: Jan 16, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

24.9K
Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

10.0K
Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues
07:17

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

1.8K

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

9.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.4K

Articles linked to this work by shared authors, journal, and citation graph.

Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance.

NPJ genomic medicine·2026

Erdheim-Chester disease associated with myeloid neoplasm: Clinical features, molecular landscape, and treatment outcomes.

HemaSphere·2026

A specific bone marrow cytokine pattern in de novo acute myeloid leukemia.

Clinical immunology (Orlando, Fla.)·2025

The TP53 tumor suppressor gene: From molecular biology to clinical investigations.

Journal of internal medicine·2025

The Broad Spectrum of TP53 Mutations in CLL: Evidence of Multiclonality and Novel Mutation Hotspots.

Human mutation·2025

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.

Nature genetics·2025

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy.

Leukemia·2026

Cheminformatic identification of small molecules targeting acute myeloid leukemia.

Leukemia·2026

Ivosidenib monotherapy in IDH1 mutated myelodysplastic neoplasm/syndrome.

Leukemia·2026

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis.

Leukemia·2026

PTBP1 controls oncogenic transcript processing and maintenance of acute myeloid leukemia.

Leukemia·2026

TP53-mutant CHIP defines a pro-inflammatory phenotype and predicts adverse outcomes after CAR T-cell therapy.

Leukemia·2026

Adjuvant CDK4/6 inhibitors in early-stage breast cancer: Clinical evidence and considerations for risk stratification and treatment selection.

Cancer·2026

Predictive Value of Preoperative Chest Computed Tomography-Measured Diaphragm Thickness Combined With Pulmonary Function for Postoperative Pulmonary Complications After Anatomic Lung Resection in Elderly Patients With Clinical Stage I Non-Small Cell Lung Cancer.

The American surgeon·2026

Integrated Bulk and Single-Cell Transcriptomic Analyses Identify a Five-Gene Signature Associated With Prognosis and the Tumor Microenvironment in Epstein-Barr Virus-Associated Gastric Cancer.

Genetics research·2026

Brain Network Convergence of Abnormal Gray Matter and Functional Activity of Pathological Dissociative Symptoms.

Psychiatry and clinical neurosciences·2026

SHMT2: a Metabolic and Immune Biomarker of Aggressive Lung Adenocarcinoma.

Journal of visualized experiments : JoVE·2026

Time-dependent predictors of seizure outcome in grade 1-2 glioma-related epilepsy.

Epilepsia·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us