A Promising Biomimetic Hydrogen Sulfide System for Advancing Inflammatory Disease Treatment

Area of Science:

• Biomaterials Science
• Gas Therapy
• Inflammation Research

Background:

• Hydrogen sulfide (H2S) has a dual role in inflammatory diseases, requiring precise control for therapeutic use.
• Conventional H2S donors often lack controlled release, leading to toxicity and limited efficacy.
• Developing systems that mimic endogenous H2S production is crucial for safe and effective gas therapy.

Purpose of the Study:

• To develop an innovative, biomimetic hydrogen sulfide (H2S) supply system for controlled therapeutic delivery.
• To functionalize the system for targeted delivery to inflammatory bowel disease (IBD) tissues.
• To evaluate the system's efficacy in mitigating inflammation, repairing intestinal barriers, and modulating gut microbiota.

Main Methods:

• A biomimetic H2S supply system (CP) was designed to mimic endogenous enzymatic H2S production.
• The CP system was functionalized with hyaluronic acid to create a targeted delivery system (CPH).
• CPH was tested for its ability to deliver H2S sustainably and controllably in an inflammatory microenvironment, specifically for IBD models.

Main Results:

• The CP system demonstrated sustained and constant H2S production, ensuring therapeutic benefits without toxicity.
• CPH achieved targeted delivery to IBD tissues and controlled H2S release within the diseased microenvironment.
• CPH significantly reduced immune inflammation, promoted intestinal epithelial barrier repair, and modulated gut microbiota composition.

Conclusions:

• The developed biomimetic H2S supply system (CPH) offers a revolutionary strategy for H2S-based therapies.
• This system effectively harnesses the therapeutic potential of H2S while mitigating its adverse effects.
• The findings provide new insights into advanced gas-based therapeutic strategies for inflammatory diseases like IBD.