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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

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Structured evidence summaries designed to inform decision-makers in health research: a scoping review protocol

Ariadna Auladell-Rispau^1,2, Joanne Khabsa³, Danielle Pollock⁴

¹Institut de recerca Sant Pau (IR Sant Pau), Barcelona, Spain.

JBI Evidence Synthesis

|September 29, 2025

Abstract

Objective:

This scoping review aims to identify, summarize, and describe the content and format of structured evidence summaries designed to inform clinical or policy decisions.

Introduction:

There is a need to develop a more efficient strategy to ensure that the results of the Living Evidence approach reach end users in a timely manner, thereby enhancing their role in the decision-making process.

Eligibility Criteria:

Any article assessing the development or validation process of generating a structured evidence summary aimed at informing health decision-makers will be considered for inclusion in the review. Additionally, we will include summaries that have been published as part of the updated reports of living systematic reviews of any health-related question.

Methods:

This scoping review will be conducted in accordance with the JBI guidance for scoping reviews and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR). The initial search will be conducted in PubMed, Embase, and Cochrane, as well as websites and databases specializing in health decision-making and health technology assessment, including Health Systems Evidence, Epistemonikos, NICE Evidence Search, and websites of major European health technology assessment agencies, such as the European Network for Health Technology Assessment (EUnetHTA) and the National Institute for Health and Care Excellence (NICE). Finally, broader searches will be conducted in Google Scholar and the JBI Evidence-Based Practice Database to identify hard-to-find articles. Two researchers will independently screen, select, and extract documents, with findings presented both narratively and in tabular format.

Review Registration:

OSF https://osf.io/69chn.

Keywords:

LESS Living Evidence Living Evidence Structured Summaries structured evidence summaries

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