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Updated: Jan 16, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

Five-Year Trajectory of Mild Cognitive Impairment: Insights from a Primary Care Memory Clinic

Linda Lee1, Aaron Jones2, Tejal Patel3

  • 1Department of Family Medicine, McMaster University, Hamilton, ON, Canada and Centre for Family Medicine Family Health Team, Kitchener, ON, Canada.

Canadian Journal on Aging = La Revue Canadienne Du Vieillissement
|September 29, 2025
PubMed
Abstract

Insights

The 5-year risk of Mild Cognitive Impairment (MCI) progressing to dementia is estimated at 48.8%, with higher Montreal Cognitive Assessment (MoCA) scores indicating a lower risk. Primary care memory clinics aid early detection.

Area of Science:

  • Neurology
  • Gerontology
  • Primary Care Medicine

Background:

  • The progression of Mild Cognitive Impairment (MCI) to dementia in primary care settings remains poorly understood.
  • Early identification and intervention are crucial for managing cognitive decline.

Purpose of the Study:

  • To investigate the 5-year trajectory of patients diagnosed with MCI.
  • To assess dementia risk factors including age, sex, and Montreal Cognitive Assessment (MoCA) scores.
  • To determine the annual conversion rate from MCI to dementia in a memory clinic setting.

Main Methods:

  • A longitudinal cohort study involving a retrospective chart review of 751 patients.
  • Utilized Kaplan-Meier method for conversion rate estimation.
  • Employed Cox regression to analyze time to dementia and MoCA score association.

Main Results:

  • The estimated 5-year conversion rate from MCI to dementia was 48.8%, with an average annual rate of 9.8%.
  • A one-point increase in baseline MoCA score was linked to a 10% reduced risk of dementia conversion.
  • Observed 5-year conversion rate was 28.0% with limited follow-up data.

Conclusions:

  • Highlights the characteristics of patients seen in Multispecialty Interprofessional Team (MINT) memory clinics.
  • Provides insights into the cognitive trajectory of individuals with MCI.
  • Underscores the significance of primary care-based memory clinics for early detection and intervention.
Keywords:
cliniques de la mémoiredementiadisease trajectorydémencememory clinicsmild cognitive impairmentprimary caresoins primairestrajectoire cognitivetrouble cognitif léger

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