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Updated: Jan 16, 2026

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging
Published on: January 5, 2015
Light-triggered quenching of the 19F-MRI signal from micelle-encapsulated PERFECTA
Claire Leterrier1, Guillaume Pinna2,3, Marie Vandamme2,3
1CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, Université Paris-Saclay, 91191 Gif-sur-Yvette, France. edmond.gravel@cea.fr.
Abstract:
We report the development of a fluorinated micellar nanosystem whose 19F-MRI signal can be selectively dimmed by application of an external stimulus. A photo-activatable quencher unit (ferrocene) was co-encapsulated with the superfluorinated PERFECTA probe in colloidal micelles. While pristine micelles were MRI responsive ("On" state), their irradiation by light triggered the "Off" MRI-state of PERFECTA.

