Related Experiment Video

Updated: Jan 16, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.6K

Association of Serum Uric Acid and CRP/Albumin Ratio With Contrast-Induced Nephropathy in Acute Myocardial Infarction

Arzu Akgül1, Çağatay Tunca2, Alperen Taş3

  • 1Department of Nephrology, Ministry of Health Ankara Etlik City Hospital, Turkey.

Angiology
|September 29, 2025
PubMed

Insights

Serum uric acid (SUA) and C-reactive protein/albumin ratio (CAR) predict contrast-induced nephropathy (CIN) in acute myocardial infarction (MI) patients. Higher levels of SUA and CAR are associated with increased CIN risk, aiding in patient stratification.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Contrast-induced nephropathy (CIN) is a significant complication following coronary angiography (CAG) in acute myocardial infarction (MI) patients, increasing morbidity and mortality.
  • Identifying reliable biomarkers for CIN prediction is crucial for timely intervention and improved patient outcomes.

Purpose of the Study:

  • To evaluate the predictive value of serum uric acid (SUA) and C-reactive protein/albumin ratio (CAR) for the development of CIN in patients with acute MI undergoing CAG.
  • To assess the independent predictive power of SUA and CAR and their correlation with other risk factors.

Main Methods:

  • A retrospective analysis of 1326 acute MI patients who underwent CAG was conducted.
  • Serum uric acid (SUA) and C-reactive protein/albumin ratio (CAR) levels were measured and analyzed for their association with CIN development.
  • Multivariate logistic regression and Receiver Operating Characteristic (ROC) curve analysis were employed to determine independent predictors and optimal cutoff values.

Main Results:

  • CIN developed in 9.0% of the patients.
  • Higher baseline SUA and CAR levels were significantly associated with CIN development (P < .001 and P = .004, respectively).
  • SUA (OR: 1.577, P < .001) and contrast volume (OR: 1.014, P < .001) were identified as independent predictors of CIN. An optimal SUA cutoff of 4.9 mg/dL was determined.

Conclusions:

  • Elevated serum uric acid (SUA) and high C-reactive protein/albumin ratio (CAR) are independent predictors of contrast-induced nephropathy (CIN) in acute myocardial infarction (MI) patients undergoing coronary angiography (CAG).
  • These biomarkers, along with contrast volume, age, and diabetes status, can be incorporated into a risk score to enhance CIN risk stratification and guide preventive strategies.

Keywords:
C-reactive protein/albumin ratioacute myocardial infarctioncontrast induced nephropathyinflammationuric acid

More Related Videos

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

17.1K
Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

40.8K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
540
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
260
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
364
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
215
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
577
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
190