Long non-coding RNAs: Emerging regulators of diverse programmed cell death pathways in neurons

Area of Science:

• Neuroscience
• Molecular Biology
• Genetics

Background:

• Long non-coding RNAs (lncRNAs) are key regulators in biological processes.
• lncRNAs significantly influence programmed neuronal cell death pathways.
• Dysregulation of these pathways is linked to neurodegenerative diseases and injuries.

Purpose of the Study:

• To review the roles of lncRNAs in programmed neuronal cell death.
• To focus on apoptosis, necroptosis, ferroptosis, and pyroptosis.
• To highlight the therapeutic potential of lncRNAs in neuroprotection.

Main Methods:

• Literature review of lncRNAs in neuronal cell death.
• Analysis of lncRNA involvement in apoptosis, necroptosis, ferroptosis, and pyroptosis.
• Synthesis of current understanding and future directions.

Main Results:

• lncRNAs modulate apoptosis, a critical process for neuronal development.
• lncRNAs influence necroptosis, a caspase-independent inflammatory cell death.
• lncRNAs impact pyroptosis via inflammasome pathways and ferroptosis through redox balance.

Conclusions:

• lncRNAs play multifaceted roles in various programmed neuronal cell death modalities.
• Targeting lncRNAs presents a promising therapeutic strategy for neurological conditions.
• Further research into lncRNA mechanisms can advance treatments for neuronal loss.