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Gut microbial community of patients with Parkinson's disease analyzed using metagenome-assembled genomes

Yi Zhang1, Chengjun Mo1, Xiaoqin He2

  • 1Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neural Regeneration Research
|September 29, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Parkinson’s diseaseconstipationdysbiosisgut microbiotametagenome-assembled genomesmetagenomic binningnerve regenerationshotgun metagenomic sequencingα-synuclein

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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