PARP-1 rs1136410 Polymorphism and Gastrointestinal Cancer Risk: A Meta-Analysis of Cancer-Type and Ethnic-Specific...

Area of Science:

• Genetics and Genomics
• Oncology
• Molecular Biology

Background:

• Poly (ADP-ribose) polymerase-1 (PARP-1) is crucial in DNA repair and linked to cancer susceptibility.
• The PARP-1 rs1136410 polymorphism shows inconsistent associations with gastrointestinal cancer risk across different populations.

Purpose of the Study:

• To evaluate the association between the PARP-1 rs1136410 polymorphism and the risk of colorectal cancer (CRC) and gastric cancer (GC).
• To investigate potential ethnic differences in the association between PARP-1 rs1136410 and gastrointestinal cancer risk.

Main Methods:

• Systematic literature search across multiple databases up to February 1, 2025.
• Inclusion of eligible case-control studies assessing the PARP-1 rs1136410 polymorphism and CRC or GC risk.
• Pooled odds ratios (ORs) and 95% confidence intervals (CIs) calculated under five genetic models using Comprehensive Meta-Analysis software.

Main Results:

• Thirteen studies (3,591 cases, 5,433 controls) were included.
• Significant associations between PARP-1 rs1136410 and increased GC risk were found under multiple genetic models (e.g., allele comparison OR=2.01, homozygous CC vs. TT OR=1.77).
• No significant association was detected for CRC risk; however, ethnic subgroup analysis indicated a protective effect in Caucasians and increased susceptibility in Asians.

Conclusions:

• The PARP-1 rs1136410 polymorphism is associated with elevated gastric cancer risk but not colorectal cancer.
• Ethnicity-dependent effects highlight differential genetic susceptibility to gastrointestinal cancers.
• Findings emphasize the importance of population-specific genetic backgrounds for cancer risk assessment and precision medicine.