Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

903
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
903
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

549
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
549
Liver Regeneration01:24

Liver Regeneration

4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

313
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
313
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

667
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
667

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter: Attempted Validation of Villin-1 as a Gut Barrier Marker in Decompensated Cirrhosis-Potential Confounding by Tubular Injury and Aetiology.

Alimentary pharmacology & therapeutics·2026
Same author

Machine Learning Predicts Hepatocellular Carcinoma Risk from Routine Clinical Data: A Large Population-Based Multicentric Study.

Cancer discovery·2026
Same author

Acute Variceal Bleeding During the SARS-CoV-2 Pandemic: A National Multicenter Observational Study.

Journal of clinical medicine·2025
Same author

SARS-CoV-2 Antibody Prevalence Across Unvaccinated Health Care Workers During the COVID-19 Pandemic in Yemen: Cross-Sectional Study.

JMIR public health and surveillance·2025
Same author

The prognostic significance of HDL-associated apolipoproteins in ascitic fluid from patients with cirrhosis and spontaneous bacterial peritonitis.

Scientific reports·2025
Same author

Surrogate Markers of Intestinal Permeability, Bacterial Translocation and Gut-Vascular Barrier Damage Across Stages of Cirrhosis.

Liver international : official journal of the International Association for the Study of the Liver·2025

Related Experiment Video

Updated: Jan 16, 2026

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.9K

Peritoneal immunity in decompensated cirrhosis.

Oluwatomi Ibidapo-Obe1, Michael D Rooney2, Tony Bruns1

  • 1Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany.

Expert Review of Clinical Immunology
|September 29, 2025
PubMed
Summary

In cirrhosis with ascites, gut barrier dysfunction allows bacterial products into the abdomen, activating immune cells. This review explores how these immune cells in the peritoneum become dysfunctional, increasing infection risk.

Keywords:
T cellsascitesbacterial translocationcirrhosisimmunitymacrophagesperitonitis

More Related Videos

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.9K
Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
09:48

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Published on: September 26, 2019

16.6K

Related Experiment Videos

Last Updated: Jan 16, 2026

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
06:45

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis

Published on: December 18, 2010

19.9K
Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
07:32

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

1.9K
Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
09:48

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Published on: September 26, 2019

16.6K

Area of Science:

  • Immunology
  • Hepatology
  • Microbiology

Background:

  • Cirrhosis and ascites lead to intestinal barrier failure and immune dysfunction.
  • This facilitates bacterial translocation into the peritoneal cavity, promoting inflammation and infection.
  • Spontaneous bacterial peritonitis (SBP) is a common complication in these patients.

Purpose of the Study:

  • To review recent research on human peritoneal immunity in decompensated cirrhosis.
  • To focus on the altered states of peritoneal macrophages, T cells, and neutrophils.
  • To understand their role in peritoneal inflammation and infection.

Main Methods:

  • Narrative review of existing literature.
  • Focus on human studies of peritoneal immune cells.
  • Analysis of immune cell composition and function.

Main Results:

  • Peritoneal immune cells in decompensated cirrhosis exhibit chronic activation and dysfunction.
  • This altered immune state contributes to increased inflammation and infection susceptibility.
  • Specific cell types discussed include macrophages, T cells, and neutrophils.

Conclusions:

  • Targeting peritoneal immune cells offers potential strategies for infection prevention and inflammation mitigation.
  • Strategies include modulating macrophage priming, innate immune memory, and inflammatory mediators.
  • Further research is needed to develop effective clinical immunomodulatory interventions.