Related Experiment Video
Updated: Jan 16, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
Published on: November 26, 2015
Assessment of Anesthetic Modalities in Otologic Surgery
Phuong H Bao1, David R Friedland2, Jazzmyne A Adams1
1Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.
Objective:
Otologic surgery has specific anesthetic requirements such as avoiding nitrous oxide and allowing facial nerve monitoring, but lacks clear criteria for an optimal anesthetic regimen, often relying on anesthesiologist preference.
Study Design:
This study is a retrospective review of 600 primary cochlear implant surgeries and anesthetic variables.
Setting:
This study was conducted in a tertiary academic medical center.
Methods:
Univariate, multivariate, and cluster analyses of anesthetic regimen association with clinical metrics of postoperative recovery.
Results:
Among 600 cochlear implant surgeries, anesthesia regimens included balanced (combination of gas and intravenous agents) (84.3%), gas alone (13.5%), and total intravenous anesthesia (TIVA) (2.2%). By univariate analysis, emergence from anesthesia was shortest with TIVA (11.9 ± 4.6 minutes) and longest with gas (14.2 ± 5.3 minutes), although not reaching statistical significance. Univariate analyses also failed to show a significant correlation between anesthesia regimen and phase I recovery or phase II duration. Multivariate regression indicated significantly shorter emergence times with TIVA compared with gas alone (coeff: -5.29, P = 0.0027). Cluster analysis identified 3 groups based on relative remifentanil and gas usage. Patients in cluster 1 (low gas and high remifentanil) had significantly longer emergence times than those in clusters 2 (low gas, low remifentanil: 16.26 ± 5.96 vs 13.39 ± 5.30 minutes; P = 0.001) and 3 (high gas, low remifentanil: 16.26 ± 5.96 vs 13.47 ± 5.48 minutes; P = 0.0069). Cluster 1 also had longer phase 1 recovery times compared with clusters 2 (65.33 ± 28.87 vs 54.33 ± 25.36 minutes; P = 0.0085) and 3 (65.33 ± 28.87 vs 56.38 ± 20.81 minutes; P = 0.0365).
Conclusion:
TIVA anesthetic regimen is associated with shorter emergence time than gas alone, although the difference in time is small. Balanced regimens are most used among anesthesiologists, and limiting remifentanil dosage may shorten emergence and recovery times.
Related Concept Videos
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Parenteral Anesthetics: Overview
Local Anesthetics: Clinical Application as Spinal Anesthesia
Stages of General Anesthesia

