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Common Femoral Vein Wall Thickness as a Diagnostic Marker for Behçet's Disease: A Case-Control Study
Raghad Tarcha1, Muttaz Hanna2, Mohamad Ali Nahas3
1Department of Rheumatology, Faculty of Medicine Damascus University Damascus Syria.
Insights
Measuring common femoral vein (CFV) wall thickness via ultrasound can help diagnose Behçet
Area of Science:
- Vascular Medicine
- Diagnostic Imaging
- Rheumatology
Background:
- Behçet's Disease (BD) diagnosis is challenging.
- Measuring common femoral vein (CFV) wall thickness is a potential diagnostic indicator.
- Previous studies suggest CFV wall thickness may be valuable in BD diagnosis.
Purpose of the Study:
- To assess the diagnostic utility of venous Doppler ultrasound for CFV wall thickness in Behçet's Disease.
- To differentiate BD patients from healthy controls (HCs) using CFV wall thickness.
- To explore the correlation between CFV wall thickness and BD clinical manifestations.
Main Methods:
- Venous Doppler ultrasound was used to measure CFV wall thickness in 96 participants (48 BD patients, 48 HCs).
- Bilateral CFV wall thickness measurements were compared between groups.
- Statistical analyses determined diagnostic cutoff values and correlations.
Main Results:
- CFV whole-wall thickness (WWT) was significantly higher in BD patients compared to HCs (p < 0.001).
- A CFV WWT cutoff of ≥0.668 mm showed 89.6% sensitivity and 100% specificity for differentiating BD.
- Thicker CFV walls were noted in BD patients with vascular involvement.
Conclusions:
- Ultrasound measurement of CFV wall thickness is a promising noninvasive tool for diagnosing BD.
- This method can effectively distinguish BD patients from healthy individuals.
- CFV wall thickness may serve as a marker for BD vascular involvement and disease severity.
Background And Aims:
Recent publications have highlighted the potential diagnostic value of measuring common femoral vein (CFV) wall thickness in Behçet's Disease (BD). The diagnosis of BD remains a clinical challenge. The objective of this study is to evaluate the utility of venous Doppler ultrasound measurement of CFV wall thickness as a diagnostic tool for BD and to differentiate it from healthy controls (HCs).
Methods:
A total of 96 individuals were included: 48 patients with BD and 48 HCs. CFV wall thickness was measured bilaterally using venous Doppler ultrasound. Comparative statistical analyses were performed between groups, and diagnostic cutoff values were determined.
Results:
Both right and left whole-wall thickness (WWT) of the CFV were significantly higher in the BD group compared to HCs (p < 0.001). A diagnostic cutoff value of ≥ 0.668 mm for CFV WWT effectively distinguished BD from HCs, with a sensitivity of 89.6% and specificity of 100%. Among BD patients, those with vascular involvement had notably thicker CFV walls. No significant correlations were observed with ocular, neurological, articular, or gastrointestinal involvement, nor with laboratory markers or most treatment modalities.
Conclusion:
Ultrasound assessment of CFV wall thickness is a promising, noninvasive diagnostic tool that may aid in differentiating BD from healthy individuals. Its significant association with vascular involvement further supports its role as a potential marker of disease severity.
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