Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Flow Cytometry01:23

Flow Cytometry

15.7K
The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...
15.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Venetoclax in combination with cytarabine with or without idarubicin or azacitidine in children, adolescents, and young adults with relapsed or refractory acute myeloid leukaemia (VENAML): a multicentre, phase 1 expansion study.

The Lancet. Haematology·2026
Same author

Quantifying interpretive contributions to analytical variability in clinical flow cytometry.

Cytometry. Part B, Clinical cytometry·2026
Same author

Educational Interventions for the Timely Diagnosis of Pediatric Patients With Cancer: A Scoping Review.

JCO global oncology·2026
Same author

​EuroNet-PHL-LP1: Complete resection or low-dose chemo for pediatric low-risk nodular lymphocyte-predominant Hodgkin lymphoma.

Blood advances·2026
Same author

Presentation and management of pediatric T-cell acute lymphoblastic leukemia with mediastinal mass and hyperleukocytosis.

Haematologica·2026
Same author

Distinct volatile profiles of Metschnikowia pulcherrima L672 and Hanseniaspora uvarum L793 determine their antagonistic efficacy against Aspergillus flavus in a dried fig agar model.

International journal of food microbiology·2026

Related Experiment Video

Updated: Jan 16, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

17.1K

Enhancing diagnostics through flow cytometry: overcoming barriers in low resource settings.

Jeanine Alfaro1, Patricia Valverde1, Paola Salguero1

  • 1Department of Pediatrics, Unidad de Oncología Pediátrica, Guatemala City, Guatemala.

Frontiers in Oncology
|September 29, 2025
PubMed
Summary

Flow cytometry (FC) is crucial for detecting measurable residual disease (MRD) in acute lymphoblastic leukemia (ALL). This study addresses challenges in implementing FC-based MRD assays in low-resource settings to improve patient survival.

Keywords:
acute lymphoblastic leukemiaflow cytometrylow- and middle-income countriesminimal residual diseasepediatric

More Related Videos

Characterizing Microbiome Dynamics – Flow Cytometry Based Workflows from Pure Cultures to Natural Communities
09:57

Characterizing Microbiome Dynamics – Flow Cytometry Based Workflows from Pure Cultures to Natural Communities

Published on: July 12, 2018

12.5K
Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology
13:59

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

14.1K

Related Experiment Videos

Last Updated: Jan 16, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

17.1K
Characterizing Microbiome Dynamics – Flow Cytometry Based Workflows from Pure Cultures to Natural Communities
09:57

Characterizing Microbiome Dynamics – Flow Cytometry Based Workflows from Pure Cultures to Natural Communities

Published on: July 12, 2018

12.5K
Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology
13:59

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

Published on: November 13, 2014

14.1K

Area of Science:

  • Hematology
  • Oncology
  • Clinical Diagnostics

Background:

  • Acute lymphoblastic leukemia (ALL) survival rates are inconsistent, influenced by subtype and geography.
  • Accurate diagnosis and monitoring, including immunophenotyping and measurable residual disease (MRD) detection, are vital for effective ALL management.
  • Flow cytometry (FC) provides sensitive and rapid MRD detection, surpassing traditional methods.

Purpose of the Study:

  • To discuss the design, implementation, and validation of MRD detection strategies using FC.
  • To address the barriers limiting FC-based MRD assay adoption in low- and middle-income countries (LMIC).
  • To explore potential improvements in accessibility and patient outcomes in resource-constrained settings.

Main Methods:

  • The study focuses on designing, implementing, and validating MRD detection strategies using flow cytometry (FC).
  • It specifically addresses the challenges encountered in resource-limited environments.
  • Key considerations include technical complexity, operator expertise, and cost of reagents and quality control.

Main Results:

  • Flow cytometry (FC) offers superior sensitivity and speed for measurable residual disease (MRD) detection in acute lymphoblastic leukemia (ALL) compared to conventional methods.
  • Significant barriers, including technical complexity, expertise requirements, and high costs, hinder the widespread adoption of FC-based MRD assays in low- and middle-income countries (LMIC).
  • The study outlines strategies for designing, implementing, and validating these assays in resource-constrained settings.

Conclusions:

  • Addressing the challenges of technical complexity, expertise, and cost is crucial for implementing FC-based MRD assays in LMIC.
  • Successful implementation can significantly improve the accessibility of advanced diagnostic tools for ALL patients.
  • Enhanced accessibility to FC-based MRD detection holds the potential to improve patient outcomes in resource-limited settings.