Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Antiepileptic Drugs: Glutamate Antagonists

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Interplay of Parental Leave, Career Achievement, and Burnout in Academic Neurologists: A Multicenter Study.

Journal of women's health (2002)·2026

Same author

Impact of Caregiver Status on Academic Achievements and Family-Work Conflict: A Cross-Sectional Analysis of US Neurology Faculty.

Neurology. Clinical practice·2025

Same author

infomeasure: a comprehensive Python package for information theory measures and estimators.

Scientific reports·2025

Same author

Evaluating Methods for Detrending Time Series Using Ordinal Patterns, with an Application to Air Transport Delays.

Entropy (Basel, Switzerland)·2025

Same author

Comparing temporal and aggregated network descriptions of fluid transport in the Mediterranean Sea.

Physical review. E·2025

Same author

Optical Coherence Tomography Angiography: Investigating Vessel Density Changes Induced by Caffeine in Healthy Subjects.

Journal of ophthalmology·2024

Same journal

Mind the gender gap: how defining head trauma increases reporting in women aged 30-50.

Frontiers in neurology·2026

Same journal

Traditional Chinese medicine interventions for post-stroke cognitive impairment: an evidence mapping.

Frontiers in neurology·2026

Same journal

Acupuncture is independently associated with improved recovery in Guillain-Barré syndrome: a prospective observational study.

Frontiers in neurology·2026

Same journal

A convergence of global epidemics: diabetes as a modulator of neurodegenerative and neuro-inflammatory disorders.

Frontiers in neurology·2026

Same journal

Lumbar puncture opening pressure, brain network hub integrity, and delirium in herpes simplex virus encephalitis: a prospective cohort study.

Frontiers in neurology·2026

Same journal

Sleep deprivation: a comprehensive review of multisystem impacts, underlying mechanisms, and emerging interventions.

Frontiers in neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 16, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Ethambutol optic neuropathy.

Padmaja Sudhakar¹, Kishor Acharya¹, Tonse Ashwini Kini²

¹Department of Neurology and Ophthalmology, University of Kentucky, Lexington, KY, United States.

Frontiers in Neurology

|September 29, 2025

Summary

This summary is machine-generated.

Ethambutol toxic optic neuropathy is a serious side effect of this tuberculosis drug. Increased use of ethambutol may lead to more cases, requiring careful monitoring and management.

Keywords:

antitubercular therapy arabinosyl transferase ethambutol mycobacteria optic neuropathy

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Related Experiment Videos

Last Updated: Jan 16, 2026

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Area of Science:

Ophthalmology
Neurology
Pharmacology

Background:

Ethambutol is a key antitubercular drug used globally for Mycobacterium tuberculosis infections.
Ethambutol toxic optic neuropathy is a significant adverse effect, alongside peripheral neuropathy and gastrointestinal issues.
Revised tuberculosis treatment guidelines may increase ethambutol usage and associated optic neuropathy risk.

Purpose of the Study:

To review the clinical features of ethambutol toxic optic neuropathy.
To outline neuro-ophthalmic evaluation, screening, and diagnostic methods.
To discuss current treatment strategies for ethambutol-induced optic neuropathy.

Main Methods:

Minireview of existing literature on ethambutol toxic optic neuropathy.
Synthesis of clinical presentations and diagnostic approaches.
Analysis of treatment options and management guidelines.

Main Results:

Ethambutol toxic optic neuropathy presents with characteristic visual disturbances.
Early detection through neuro-ophthalmic evaluation is crucial for management.
Prompt discontinuation of ethambutol and supportive care are primary treatment steps.

Conclusions:

Ethambutol toxic optic neuropathy is a preventable and manageable condition with timely diagnosis.
Increased ethambutol use necessitates heightened awareness and screening protocols.
Further research into novel therapeutic interventions is warranted.