Related Experiment Video
Updated: Jan 16, 2026
The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb
Published on: September 23, 2018
The effectiveness of intermittent theta burst stimulation for upper limb motor recovery after stroke: an exploratory
Songbin Chen1,2, Xiaotong Li2, Wenqing Yang2,3
1Neurorehabilitation Laboratory, Department of Rehabilitation Medicine, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Background:
Stroke often results in significant motor impairments, particularly in the upper limbs, which can severely impact functional independence and quality of life. Conventional rehabilitation methods provide limited recovery, necessitating the exploration of adjunctive therapies to enhance motor function. Intermittent theta burst stimulation (iTBS) is a brain stimulation technique that has shown promise in improving motor function after stroke. This study was conducted to investigate whether iTBS targeting ipsilesional primary motor cortex can induce improvements of the paretic upper limb and physiological changes in cortical excitability in subacute stroke patients.
Methods:
50 patients were randomized assigned to either iTBS or sham stimulation across 10 sessions. Motor function, symptom severity, muscle tone, and functional independence were evaluated. Additional measures included rest motor threshold (RMT), oxygenated hemoglobin concentration.
Results:
Both the iTBS and sham groups showed significant improvements in National Institutes of Health Stroke Scale (NIHSS) (iTBS: p = 0.002; sham: p = 0.039), Fugl-Meyer Assessment (FMA) (iTBS: p < 0.001; sham: p = 0.005), and Modified Barthel Index (MBI) (iTBS: p < 0.001; sham: p = 0.002) scores post-intervention. Only the iTBS group demonstrated significant improvements in Modified Ashworth Scale (MAS) (p < 0.001), Wolf Motor Function Test (WMFT) (p < 0.001), and RMT (p = 0.016). The iTBS group exhibited a trend toward greater improvements in MAS (p = 0.001), WMFT (p = 0.002), and MBI (p < 0.001). RMT in contralateral Primary motor cortex (M1) was significantly lower in the iTBS group (p = 0.016), and functional connectivity between each M1 regions was notably enhanced (p = 0.049).
Conclusion:
These findings suggest that iTBS may offer additional benefits in improving functional task performance and cortical connectivity in subacute stroke patients.
Clinical Trial Registration:
https://www.chictr.org.cn/showproj.html?proj=193454, Identifier ChiCTR2300072415.
More Related Videos
08:53Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
05:28Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies
Published on: October 11, 2024