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Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Exosomal miRNAs as biomarkers in predicting chemotherapy-induced cardiotoxicity in patients with cancer (Review)

Vedant Shah1, Viraj Panchal2, Abhi Shah2

  • 1Department of Internal Medicine, The New York Medical College Graduate Medical Education Program at St. Mary's General Hospital and Saint Clare's Health, Denville, NJ 07834, USA.

Medicine International
|September 29, 2025
PubMed

Insights

Exosomal microRNAs (miRNAs) show promise for early detection of cancer therapy-related cardiotoxicity. These biomarkers can identify subclinical cardiac changes, enabling timely interventions and personalized cardioprotective strategies.

Area of Science:

  • Cardiology
  • Oncology
  • Biomarkers

Background:

  • Cancer therapies like targeted therapies and immune checkpoint inhibitors improve patient outcomes but increase cardiotoxicity risk.
  • Cardiotoxicity ranges from subclinical dysfunction to severe cardiomyopathy, necessitating early detection and prevention.
  • Traditional biomarkers like troponins indicate damage post-injury, limiting early intervention.

Purpose of the Study:

  • To review the role of exosomal microRNAs (miRNAs) as early diagnostic biomarkers for cardiotoxicity induced by chemotherapeutic agents.
  • To highlight the potential of exosomal miRNAs in enabling timely intervention and personalized cardioprotective strategies.
  • To discuss the therapeutic potential of exosomal miRNAs in modulating cardiotoxicity-related molecular pathways.

Main Methods:

  • Literature review focusing on exosomal microRNAs (miRNAs) and their association with chemotherapy-induced cardiotoxicity.
  • Analysis of studies investigating miRNAs as non-invasive biomarkers for myocardial stress and damage.
  • Exploration of miRNA regulatory mechanisms in cardiotoxicity.

Main Results:

  • Exosomal miRNAs are stable in biological fluids and can reflect early myocardial stress and damage.
  • miRNAs offer earlier detection of subclinical cardiac changes compared to traditional biomarkers.
  • Exosomal miRNAs possess diagnostic potential and therapeutic possibilities for cardiotoxicity.

Conclusions:

  • Exosomal miRNAs are promising non-invasive biomarkers for the early diagnosis of cardiotoxicity.
  • Understanding exosomal miRNA expression is crucial for developing personalized cardioprotective strategies.
  • Exosomal miRNAs can aid in minimizing cardiovascular complications during cancer therapy.
Keywords:
cardiotoxicitychemotherapy-induced cardiotoxicityexosomal microRNAs

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