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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Zoster Sine Herpete: An Unusual Presentation.
Abdelnassir Abdelgabar1, Ayesha Farooq1, Quratulain Jabbar1
1General Internal Medicine and Acute Medicine, Diana, Princess of Wales Hospital, Grimsby, GBR.
Varicella zoster virus (VZV) reactivation can cause encephalitis without shingles (zoster sine herpete). This case highlights diagnosing VZV encephalitis using PCR and CSF analysis in an immunocompetent patient.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Varicella zoster virus (VZV) causes chickenpox and establishes latency in neurons.
- Reactivation typically manifests as herpes zoster (shingles), often with post-herpetic neuralgia.
- Zoster sine herpete (ZSH) is a rare VZV reactivation without skin lesions, complicating diagnosis.
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