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3D-Printed Polysaccharide Scaffolds with NIR-Triggered Activity for Diabetic Wound Healing
Brianda M Salazar Salas1, Denis Scaini2,3,4,5, Luis Fernando López Soto6
1Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Hermosillo, Sonora 83000, Mexico.
ACS Omega
|September 29, 2025
Summary
This study introduces a novel 3D-printed nanocomposite scaffold that accelerates skin regeneration in diabetic rats. Near-infrared irradiation of the scaffold significantly enhanced wound healing, offering a promising solution for diabetic wound care.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Diabetic patients face significant challenges in skin restoration due to hyperglycemia impairing angiogenesis, cell regeneration, and inflammation control.
- Delayed healing in diabetes increases infection risk and complications.
- Photothermal irradiation is an emerging strategy for accelerating tissue repair.
Purpose of the Study:
- To develop novel three-dimensional (3D)-printed, near-infrared (NIR)-responsive scaffolds for enhanced skin regeneration in diabetic models.
- To evaluate the efficacy of these scaffolds, with and without polydopamine nanoparticles, in promoting wound healing.
Main Methods:
- Fabrication of 3D multicomponent scaffolds using chondroitin sulfate, hyaluronic acid, alginate, and nanofibrillated cellulose, incorporating polydopamine nanoparticles.
- Characterization of scaffold morphology, swelling, and biocompatibility.
- In vitro scratch assay to assess keratinocyte migration and proliferation.
- In vivo studies on diabetic rats to evaluate wound closure acceleration and tissue regeneration under NIR irradiation.
Main Results:
- The 3D scaffolds demonstrated suitable morphology, swelling, and biocompatibility for wound dressing applications.
- In vitro assays confirmed the scaffold's ability to promote keratinocyte migration and proliferation.
- In vivo studies showed accelerated wound closure in diabetic rats treated with NIR-irradiated scaffolds, resulting in narrower scars and denser dermis.
- Complete wound healing was achieved 8 days earlier with the nanocomposite scaffold under NIR irradiation compared to controls.
Conclusions:
- The developed NIR-responsive 3D-printed nanocomposite scaffold is a promising platform for enhancing skin regeneration.
- Multifunctional, NIR-responsive biomaterials hold significant therapeutic potential for challenging diabetic wound models.
- This innovative scaffold represents a new approach to addressing complex tissue regeneration in diabetic patients.
