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Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

190
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
190
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
321
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

425
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Evaluating disease burden in chronic kidney disease screening using a micro-simulation model.

Yang Li1, Yuqin Ma1, Pei Liu2

  • 1Department of Health Service Management, Faculty of Health Service, Naval Medical University, Shanghai, China.

Frontiers in Public Health
|September 29, 2025
PubMed
Summary

Targeted screening for chronic kidney disease (CKD) in high-risk individuals, including those with hypertension, diabetes, and over 65, can significantly reduce end-stage renal disease cases and associated costs.

Keywords:
chronic renal insufficiencycost of illnessdisease burdenmicro-simulationscreening interventions

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Area of Science:

  • Nephrology
  • Public Health
  • Health Economics

Background:

  • Chronic kidney disease (CKD) presents a significant global health challenge due to its high prevalence, poor prognosis, substantial medical costs, and low public awareness.
  • Effective screening and intervention strategies are crucial for mitigating the growing burden of CKD.

Purpose of the Study:

  • To simulate and analyze the evolution of CKD burden in high-risk populations in Shanghai.
  • To evaluate the impact of different screening intervention strategies on CKD progression and outcomes.
  • To provide a quantifiable basis for selecting optimal CKD screening interventions.

Main Methods:

  • A micro-simulation model was developed using data from CKD screening in Shanghai's Jing'an and Minhang Districts (2015-2020).
  • SAS Statistical Software 9.4 was employed to simulate disease burden under various screening intervention scenarios.

Main Results:

  • Screening interventions targeting individuals with hypertension, diabetes, and aged 65 or older are projected to prevent 6,250 cases of end-stage renal disease by 2033.
  • These interventions could reduce end-stage renal disease by 58.36% compared to no screening, improving quality of life and reducing economic burden.

Conclusions:

  • Integrating prevention and treatment approaches for chronic diseases is vital for enhancing CKD screening and intervention.
  • Targeted screening of high-risk groups (hypertension, diabetes, age ≥65) effectively reduces end-stage renal disease, lowers healthcare costs, and improves population quality of life.