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Postorgasmic Side Effects of Tadalafil: A Case Report.

S M Yasir Arafat1,2, Sadeed Hossain3, Md Rokon Uddin4

  • 1Department of Psychiatry Bangladesh Specialized Hospital Dhaka Bangladesh.

Clinical Case Reports
|September 29, 2025
PubMed
Summary

Tadalafil, used for erectile dysfunction, can cause post-orgasmic side effects like dizziness and palpitations. Stopping the medication resolved these adverse events in one patient.

Keywords:
BangladeshPDE5 inhibitorcase reportpostorgasmic illness syndrometadalafil

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Area of Science:

  • Pharmacology
  • Urology
  • Clinical Case Reports

Background:

  • Tadalafil is a phosphodiesterase type 5 inhibitor commonly prescribed for erectile dysfunction.
  • While generally well-tolerated, understanding potential adverse effects is crucial for patient safety.

Purpose of the Study:

  • To report a case of unusual postorgasmic side effects associated with low-dose tadalafil use.
  • To highlight the importance of recognizing and managing drug-related adverse events.

Main Methods:

  • A single patient case study is presented.
  • Clinical observation and medication discontinuation were used to assess causality.

Main Results:

  • The patient experienced dizziness, palpitations, headache, and anxiety minutes after ejaculation while taking tadalafil 2.5 mg.
  • All symptoms resolved completely upon cessation of tadalafil therapy.

Conclusions:

  • Low-dose tadalafil may be associated with delayed postorgasmic adverse effects in some individuals.
  • Careful patient monitoring and consideration of drug causality are essential when managing erectile dysfunction treatments.