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Comparison of coronary artery disease involvement in patients with or without familial history
Ramin Khameneh Bagheri1, Hosna Hosseini Moghaddam2, Mostafa Ahmadi1
1Interventional Cardiologist, Department of Cardiovascular Diseases, Faculty of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
A positive family history (FH) is linked to more severe coronary artery disease (CAD) in Iranian patients. Understanding FH can help identify individuals at higher risk for targeted prevention and treatment strategies.
Area of Science:
- Cardiology
- Genetics
- Public Health
Background:
- Family history (FH) and genetic factors are significant contributors to coronary artery disease (CAD) risk.
- Limited data exists on the association between FH and CAD patterns in the Iranian population.
Purpose of the Study:
- To assess CAD involvement patterns in Iranian patients with and without a positive FH.
- To identify risk factors differentiating between these groups.
Main Methods:
- A cross-sectional study involving 300 patients with confirmed CAD from April 2019 to April 2020 in Mashhad, Iran.
- Patients were divided into two groups based on FH of CAD.
- Multivariate logistic regression was used to evaluate risk factors.
Main Results:
- 170 patients had a positive FH, while 130 did not.
- Age, male gender, and hypertension were significant differentiators between FH groups.
- Positive FH was independently associated with more extensive and severe CAD, including multivessel involvement.
Conclusions:
- A positive FH is strongly associated with increased severity and extent of CAD in Iranian patients.
- Integrating FH into risk stratification can enhance the identification of high-risk individuals.
- This can lead to more targeted preventive and therapeutic strategies for CAD.
Introduction:
Family history (FH) and genetic factors contribute significantly to coronary artery disease (CAD) risk. Given limited data on this association in the Iranian population, this study assessed CAD involvement patterns among patients with and without positive familial history.
Methods:
This cross-sectional study was conducted from April 2019 to April 2020 at Imam Reza and Ghaem Hospitals, Mashhad, Iran. We enrolled 300 patients who presented with typical chest pain and confirmed CAD via coronary angiography. Participants were divided into two groups based on FH of CAD and evaluated for potential risk factors.
Results:
Of 300 patients, 170 had positive FH and 130 did not. The cohort included 175 males (58.3 %) with a mean age of 54.2 years. Multivariate logistic regression identified age (OR: 1.04, p = 0.014), male gender (OR: 0.56, p = 0.035), and hypertension (OR: 1.99, p = 0.008) as significant differentiators between FH groups. Positive FH was independently associated with more extensive CAD, including multivessel involvement and greater severity of disease.
Conclusion:
Positive familial history is strongly associated with increased severity and extent of CAD in Iranian patients. Incorporating FH into risk stratification can improve identification of high-risk individuals for targeted preventive and therapeutic strategies.
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