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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
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COVID-19 Influence on Mandibular Dry Socket Occurrence.

Navid Kazemian1, Mozhgan Khorami1, Ricardo Grillo2

  • 1Student Research Committee, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.

World Journal of Plastic Surgery
|September 29, 2025
PubMed
Summary

Alveolar osteitis (dry socket) risk increases after mandibular third molar extraction, especially with COVID-19 hospitalization. Females face higher risks, highlighting the need for targeted prevention strategies.

Keywords:
COVID-19Dry SocketOral SurgeryOsteitisPostoperative ComplicationsSurgery

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Area of Science:

  • Oral Surgery
  • Infectious Diseases
  • Public Health

Background:

  • Alveolar osteitis (dry socket) is a common complication after tooth extraction, particularly mandibular third molars.
  • The COVID-19 pandemic's hematologic effects necessitate investigating its impact on dry socket risk.

Purpose of the Study:

  • To assess the relationship between COVID-19 and dry socket risk in patients undergoing mandibular third molar extraction.
  • To identify demographic and clinical factors associated with dry socket development post-extraction.

Main Methods:

  • Retrospective review of patient records from mandibular third molar extractions in 2022.
  • Data collection included demographics, medical history, smoking, and COVID-19 status (history, hospitalization, vaccination).

Main Results:

  • Nearly 50% of patients developed dry socket; 94% had a COVID-19 history, and 32.7% were hospitalized for COVID-19.
  • Females had a significantly higher risk of dry socket compared to males.
  • No direct link between COVID-19 infection and dry socket was found, but hospitalization showed a correlation.

Conclusions:

  • Dry socket risk is elevated by corticosteroid use, oral contraceptives, smoking, and COVID-19 hospitalization.
  • Further research is needed to understand the link between COVID-19, hospitalization, and dry socket incidence.