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Clinical Outcomes of Out-of-Hospital Cardiac Arrest with ROSC: Insights from a Specialized Referral Center in Vietnam

  • 0Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City. Vietnam.
Acta Informatica Medica : Aim : Journal of the Society for Medical Informatics of Bosnia & Herzegovina : Časopis Društva Za Medicinsku Informatiku Bih +

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September 29, 2025

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September 29, 2025

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Summary

This summary is machine-generated.

Out-of-hospital cardiac arrest (OHCA) survival is 44.2%, with lower Glasgow Coma Scale (GCS) scores, reduced kidney function (eGFR), and higher epinephrine doses predicting mortality. Early risk stratification is crucial for improving outcomes in OHCA patients with return of spontaneous circulation (ROSC).

Area Of Science

  • Cardiology
  • Emergency Medicine
  • Critical Care Medicine

Background

  • Out-of-hospital cardiac arrest (OHCA) is a critical medical emergency with significant mortality.
  • Optimizing post-resuscitation care requires identifying prognostic factors in patients achieving return of spontaneous circulation (ROSC).

Purpose Of The Study

  • To evaluate clinical outcomes and predictors of in-hospital mortality in OHCA patients admitted to a tertiary referral center in Southern Vietnam.
  • To identify independent predictors of mortality in OHCA patients with ROSC.

Main Methods

  • Retrospective cohort study of OHCA patients with ROSC admitted to Cho Ray Hospital, Vietnam (Jan 2019 - June 2024).
  • Analysis of demographic and clinical variables, survival outcomes.
  • Multivariate logistic regression to identify predictors of in-hospital mortality.

Main Results

  • 86 OHCA patients with ROSC were analyzed; 44.2% in-hospital survival rate, 25.6% good neurological outcomes (CPC 1-2).
  • Independent predictors of mortality: lower Glasgow Coma Scale (GCS) scores (OR 1.42), decreased estimated glomerular filtration rate (eGFR) (OR 1.03), and higher cumulative epinephrine dose (OR 1.10).
  • A predictive model showed strong discrimination (AUC = 0.91); an epinephrine threshold of 7 mg predicted mortality (sensitivity 0.68, specificity 0.91).

Conclusions

  • In-hospital survival for OHCA patients with ROSC was 44.2%, with good neurological outcomes in 25.6%.
  • Lower GCS, reduced eGFR, and higher epinephrine doses are independently associated with increased mortality.
  • Early risk stratification and individualized post-resuscitation management are essential for improving OHCA patient outcomes.

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