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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Clinical manifestation and pathological changes of serous papillary adenofibroma: A case series
Xiaojing Zhao1, Chaoyi Yuan1,2, Xinrun Wang1
1Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
Abstract:
Serous papillary adenofibroma (SPAF) is a rare benign tumor in gynecological practice. Most patients have no symptoms and occasionally present with pelvic masses during physical examinations. SPAF consists of both fibrous and epithelial parts, which makes it easy to misdiagnose malignancies on pre-surgery examinations. Therefore, clinical and pathological features of SPAF at the Second Affiliated Hospital Zhejiang University School of Medicine (Hangzhou, China) were summarized in the present study to assist clinical practice. A total of 13 cases encountered at our hospital were collected and immunohistochemistry (IHC) staining was performed on their specimens. SPAF appears as a unilocular cystic mass on imaging. Serum estradiol and prolactin levels were elevated in certain patients. The IHC staining of SPAF was estrogen receptor-, progesterone receptor- and human epidermal growth factor receptor 2-positive but Ki-67- and p53-negative. The present study proved the sex hormone sensitivity of SPAF and the benign prognosis of patients. Magnetic resonance imaging is a promising method for differential diagnosis before surgery.
Insights
Serous papillary adenofibroma (SPAF) is a rare gynecological tumor. This study highlights its sex hormone sensitivity and benign prognosis, aiding in accurate diagnosis and management.
Area of Science:
- Gynecological pathology
- Oncology
- Endocrinology
Background:
- Serous papillary adenofibroma (SPAF) is a rare benign gynecological tumor.
- Often asymptomatic, presenting as pelvic masses, leading to potential misdiagnosis of malignancy.
- Distinguishing SPAF from malignant tumors is crucial for appropriate patient management.
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