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Updated: Jan 16, 2026

Fixation and Operational Method for Abdominal Massage in T2DM Mice
Published on: March 7, 2025
Low Circulating Metrnl Levels are Linked to Higher Abdominal Fat in Elderly T2DM Patients: A Gender-Based Study
Jiangli Pei1, Dan Zhao1, Xinhua Ye1
1Department of Endocrinology, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University., Changzhou, Jiangsu Province, People's Republic of China.
Objective:
Our study aimed to investigate the association between serum Metrnl levels and body fat distribution in type 2 diabetes mellitus (T2DM) patients.
Methodology:
A total of 281 Chinese patients with type 2 diabetes mellitus (T2DM) (195 men and 86 postmenopausal women, aged 61.37 ± 6.50 years, BMI 24.88 ± 3.10 kg/m²) were included in the study. Measurements of body composition were obtained by dual-energy X-ray absorptiometry. Univariate and multivariate regression analyses were adjusted for age, sex, body mass index (BMI), and lipid levels, specifically android (waist/abdominal-dominant) and gynoid (hip/thigh-dominant) fat deposition. Gender-stratified analyses and restricted cubic spline models were employed.
Results:
Serum Metrnl negatively correlated with A/G ratio (β = -0.01; 95% CI: -0.02~0.00) and android fat (β = -0.77; 95% CI: -1.11~-0.42). After adjustments, associations with A/G and android fat persisted, but not with gynoid fat (P > 0.05). Gender analysis showed stronger correlations in males (A/G: β = -0.02; 95% CI: -0.04~-0.01; android fat: β = -0.85; -1.28~-0.43), but not females.
Conclusion:
Lower serum levels of Metrnl were significantly associated with increased abdominal adiposity in middle-aged and elderly patients with type 2 diabetes mellitus (T2DM), with a more pronounced correlation observed in males. These findings suggest that Metrnl may play a role in regulating abdominal obesity and metabolic dysfunction in this demographic.
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