Bile acid pathways in Caprinae gut microbiota: adaptive shifts in microbial metabolism and community structure
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Caprine gut microbes transform bile acids (BAs) using unique pathways, with <i>Bacillota</i>_A dominating BA gene carriers. This distinct microbial metabolism impacts host health and nutrient absorption.
Area Of Science
- Microbial Ecology
- Host-Microbiome Interactions
- Metagenomics
Background
- The gut microbiota is crucial for host metabolism and immunity, particularly through bile acid (BA) biotransformation.
- In Caprinae animals (goats and sheep), BA metabolism is vital for nutrient absorption, immune regulation, and gut homeostasis, but the specific microbes and functions are poorly understood.
Purpose Of The Study
- To systematically characterize the microbial diversity, taxonomic composition, and BA-related metabolic pathways in Caprinae gut microbiomes.
- To identify key microbial taxa and genes involved in BA biotransformation within Caprinae.
Main Methods
- Utilized 7,530 high-quality metagenome-assembled genomes (MAGs) from Caprinae gut microbiomes.
- Employed genome annotation, phylogenetic inference, and statistical analyses to identify BA transformation pathways and enzymes.
- Conducted comparative analyses with human and pig gut microbiota.
Main Results
- Identified a diverse Caprinae gut microbiota dominated by <i>Bacillota</i>_A, with 8,290 BA-related genes found across 5,217 MAGs.
- Discovered 1,845 MAGs encoding bile salt hydrolase (BSH), a key enzyme in BA metabolism.
- Revealed a distinct BA metabolic profile in Caprinae compared to humans and pigs, with region-specific variations in microbial composition and BA metabolism along the ovine intestinal tract.
Conclusions
- The study elucidates the unique BA metabolic capabilities of Caprinae gut microbiota.
- Highlights the functional potential of BSH-carrying MAGs and their role in host-microbiota interactions.
- Provides foundational insights into Caprinae gut microbiome functions relevant to health and disease.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...