The Relationship Between Thyroid Function Status and Serum Uric Acid Levels Based on a Restricted Cubic Spline Model:...

Area of Science:

• Endocrinology
• Metabolic Health
• Epidemiology

Background:

• The relationship between thyroid function and uric acid levels is not well-established.
• Hyperuricemia is a risk factor for various metabolic and cardiovascular diseases.

Purpose of the Study:

• To investigate the correlation between thyroid disease, thyroid hormone levels, and hyperuricemia.
• To analyze the impact of different thyroid function statuses on uric acid levels.

Main Methods:

• Retrospective analysis of health screening data from the Taiyuan area.
• Categorization of participants by thyroid disease type, thyroid function indices (FT4, FT3, TSH), and serum uric acid (SUA) levels.
• Statistical analysis including logistic regression and restricted cubic spline (RCS) modeling.

Main Results:

• Prevalence rates: clinical hyperthyroidism (0.9%), subclinical hyperthyroidism (0.7%), clinical hypothyroidism (0.8%), subclinical hypothyroidism (13.7%), and hyperuricemia (16.9%).
• Hyperuricemia prevalence increased with higher FT4 and FT3, and decreased with lower TSH.
• Thyroid disease status was not significantly correlated with hyperuricemia after covariate adjustment; only FT4 showed a significant effect (OR 1.028).
• A positive dose-response relationship was observed between FT4 levels and hyperuricemia risk within the normal range, with FT4 > 16.85 pmol/L identified as a risk factor.

Conclusions:

• Thyroid disease status does not significantly influence hyperuricemia.
• Elevated free thyroxine (FT4) levels within the normal range are positively associated with an increased risk of hyperuricemia.