Related Experiment Video
Updated: Jan 16, 2026

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
Evolutionary Khovanov homology
Li Shen1, Jian Liu2,1, Guo-Wei Wei1,3,4
1Department of Mathematics, Michigan State University, MI 48824, USA.
Abstract:
Knot theory, a subfield in geometric topology, is the study of the embedding of closed circles into three-dimensional Euclidean space, motivated by the ubiquity of knots in daily life and human civilization. However, focusing on topology, the current knot theory lacks metric analysis. As a result, the application of knot theory has remained largely primitive and qualitative. Motivated by the need of quantitative knot data analysis (KDA), this work implemented the evolutionary Khovanov homology (EKH) to facilitate a multiscale KDA of real-world data. EKH considers specific metrics to filter links, capturing multiscale topological features of knot configurations beyond traditional invariants. It is demonstrated that EKH can reveal non-trivial knot invariants at appropriate scales, even when the global topological structure of a knot is simple. The proposed EKH holds great potential for KDA and machine learning applications related to knot-type data, in contrast to other data forms, such as point cloud data and data on manifolds.
More Related Videos
Related Concept Videos
Evolutionary Relationships through Genome Comparisons
What is Evolutionary History?
Convergent Evolution
Eukaryotic Evolution
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Synteny and Evolution
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
Gene Evolution - Fast or Slow?
In contrast, regions which code...

