Breast cancer metastasizing to Jaw bones as the sole primary source: Systematic review

Breast cancer has been known for its high propensity of metastasis to unusual locations and the jaw bones are one among those sites. Numerous studies examining metastatic tumours to the oral region have been described in the literature. However, the analysis of Breast cancer metastasis to the jaw bones alone has been the subject of relatively few published research studies to date. This review was conducted to examine the published cases of metastasis to jaw bones from breast cancer as the sole primary source from 1954-2023. An electronic search of the published literature was performed without publication year limitation in PubMed/ Medline, Scopus, Google Scholar, Web of Science, Science direct and Embase databases, using mesh keywords like ('Breast cancer', OR 'Breast carcinoma'), AND ('Metastasis' OR 'Metastases'), And ('Jaw' OR 'Maxilla' OR 'Mandible' OR 'Temporomandibular joint' OR 'Condyle'). We also searched all related journals manually. The reference list of all articles was also checked. Our research revealed a total of 63 relevant papers with 74 patients. The mandible was more predominantly affected jaw than the maxilla. 20% of patients died with a mean survival time of 1.8 years. To conclude, Breast cancer metastasis to the jaw bones is a rare occurrence. Careful evaluation of more number of such cases is needed in order to raise awareness of these lesions and gain a better understanding of their characteristics.reful evaluation of such cases is needed to raise awareness of these lesions and gain a better understanding of their characteristics.