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Isolation and Physiological Analysis of Mouse Cardiomyocytes
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Noncoding and coding mechanisms of aging-related heart failure with preserved ejection fraction associated with
Sankalpa Chakraborty1,2, Olivia Sloan1,2, Bryce Dickerson1,2
1Department of Biological Sciences, Arkansas State University, Jonesboro, AR 72401, USA.
Disease Models & Mechanisms
|September 29, 2025
Summary
This study identifies novel long noncoding RNAs (lncRNAs) and other markers in aging heart failure with preserved ejection fraction (HFpEF) linked to thyroid hormone (TH) dysfunction in rats. These findings may lead to new diagnostic and therapeutic strategies for HFpEF.
Area of Science:
- Cardiovascular Biology
- Molecular Biology
- Gerontology
Background:
- Heart failure with preserved ejection fraction (HFpEF) is a complex geriatric syndrome.
- Long noncoding RNAs (lncRNAs) are critical regulators in disease processes.
- The role of lncRNAs in aging-related HFpEF with thyroid hormone (TH) dysfunction is not well understood.
Purpose of the Study:
- To investigate the roles of lncRNAs in age-related HFpEF associated with TH dysfunction.
- To identify novel noncoding and coding markers for early and late stages of HFpEF.
Main Methods:
- Utilized the ZSF1 rat model at 5, 13, and 20 months of age.
- Performed echocardiography, gravimetric, histologic, microarray, and RT-qPCR analyses.
- Investigated serum TH levels and inflammatory cytokine markers.
Main Results:
- HFpEF rats exhibited decreased serum TH levels and cardiac hypertrophy.
- Three lncRNAs were significantly upregulated in 13-month-old HFpEF rats.
- lncRNA knockdown improved cell viability, enhanced by T3; novel inflammatory markers were identified.
Conclusions:
- Identified novel lncRNAs and coding/noncoding markers in aging, hypothyroid HFpEF.
- These findings suggest potential diagnostic and therapeutic targets for HFpEF.
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