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Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Secondary Spinal Cord Injury llI: Pathophysiology01:25

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
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Relationships Between Intra-Spinal Resting-State Functional Connectivity and Electrophysiology Following Spinal Cord

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Unilateral dorsal column lesions alter spinal cord functional connectivity. Functional Magnetic Resonance Imaging (fMRI) resting-state functional connectivity (rsFC) and local field potential (LFP) coherence changes were heterogeneous and not always concordant post-injury.

Keywords:
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Area of Science:

  • Neuroscience
  • Spinal Cord Injury Research
  • Functional Neuroimaging

Background:

  • Unilateral dorsal column lesions (DCL) disrupt spinal cord sensory pathways.
  • Previous studies show DCL reduces resting-state functional connectivity (rsFC) below the lesion site.
  • Understanding long-term intraspinal circuit changes is crucial for therapeutic development.

Purpose of the Study:

  • To compare changes in rsFC (fMRI) with local field potential (LFP) coherence over an extended post-injury period.
  • To investigate the temporal and spatial dynamics of intraspinal connectivity after DCL.
  • To assess the concordance between fMRI rsFC and LFP coherence measures.

Main Methods:

  • High-resolution fMRI and LFP data acquired bilaterally in monkeys at 3 and 6 months post-DCL.
  • Analysis of tactile-stimulus-evoked LFP power and coherence between dorsal horn gray matter regions.
  • Correlation analysis between LFP coherence and fMRI rsFC measures at different spinal cord levels.

Main Results:

  • Tactile-stimulus-evoked LFP power decreased on the lesion side by 3 months post-injury.
  • LFP coherences showed complex increases and decreases on lesion and non-lesion sides at 3 months.
  • By 6 months, LFP coherences were significantly reduced across multiple inter-horn pairs, with frequency-specific alterations.
  • fMRI rsFC and LFP coherence changes were weakly correlated and showed discrepancies depending on specific gray matter regions.

Conclusions:

  • DCL induces temporally and spatially heterogeneous changes in intraspinal circuits.
  • fMRI rsFC and LFP coherence are not always concordant, highlighting the need for multimodal assessment.
  • Connectivity changes are distance-dependent caudal to the lesion, with varying patterns at different time points.