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Updated: Aug 4, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Identification and validation of centrosome-related features predicting prognosis in hepatocellular carcinoma
Qingqing Wang1, Yifan Lu1, Songhai Chen1
1Department of General Surgery, The First Hospital of Jiaxing (Affiliated Hospital of Jiaxing University), Jiaxing, Zhejiang, China.
Abstract:
Hepatocellular carcinoma (HCC) is commonly linked with centrosome abnormalities that contribute to chromosomal instability and tumor progression. Four prognostic centrosome-related genes (CRGs): DYNLL1, CEP85, C10orf90, and CETN1 were utilized to develop a risk model for HCC. The model demonstrated strong prognostic reliability. Both risk score and risk group served as independent prognostic predictors for HCC. Further analyses revealed that the low-risk group was associated with metabolism and detoxification pathways and exhibited a lower abundance of M2 macrophages. Additionally, high expression levels of DYNLL1 and CETN1 were significantly correlated with poorer prognosis, with upregulation of DYNLL1 confirmed in HCC patients.
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