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Rewiring Antitumor Immunity: Targeting CLDN18.2 with Conditional 4-1BB Activation

Giulia Pretelli1,2, Elena Garralda1,2

  • 1Early Drug Development, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|September 29, 2025
PubMed

Claudin 18.2 has emerged as a validated target in solid tumors, spurring next-generation therapies. Bispecific antibodies linking Claudin 18.2 to conditional 4-1BB activation offer a novel approach to enhance T-cell function. By confining costimulation to the tumor microenvironment, they aim to boost efficacy while limiting systemic toxicity. See related article by Ku et al., p. 4944.

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