The Potential of Resveratrol as an Anticancer Agent: Updated Overview of Mechanisms, Applications, and Perspectives

Area of Science:

• Natural product chemistry
• Molecular oncology
• Pharmacology

Background:

• Resveratrol, a polyphenol from plants, exhibits significant health benefits and anticancer properties.
• It modulates cancer-related signaling pathways via antiproliferative, proapoptotic, anti-inflammatory, and antiangiogenic mechanisms.
• Resveratrol's role in regulating oxidative stress and epigenetics adds to its therapeutic promise.

Purpose of the Study:

• To review the anticancer mechanisms of resveratrol, including structural aspects.
• To analyze its impact on signaling networks in various cancer models.
• To update knowledge on recent findings (last 5 years) and in vivo data.

Main Methods:

• Literature review focusing on recent studies (last 5 years) and in vivo data.
• Analysis of resveratrol's effects on cancer signaling pathways.
• Exploration of structural contributions to its anticancer activity.

Main Results:

• Resveratrol demonstrates broad anticancer effects through multiple molecular mechanisms.
• Its therapeutic potential is supported by preclinical data, but clinical translation faces hurdles.
• Recent research highlights specific signaling pathways and in vivo efficacy.

Conclusions:

• Resveratrol possesses significant anticancer potential, acting through diverse mechanisms.
• Clinical application is limited by bioavailability and dosage issues.
• Future strategies include novel delivery systems, drug combinations, and derivative development.