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Uveitis associated with immunotherapy and its response to monotherapy with difluprednate: A case report

C M Ortega1, A T Pérez Bello1, B F Graizman Kohan1

  • 1Centro de Ojos Lomas, Lomas de Zamora, Provincia de Buenos Aires, Argentina.

Archivos De La Sociedad Espanola De Oftalmologia
|September 29, 2025
PubMed

Nivolumab and ipilimumab are immune checkpoint inhibitors widely used for the treatment of metastatic melanoma. They can cause various adverse effects in a significant percentage of treated patients, including uveitis. Symptoms include decreased visual acuity, pain, redness, and photophobia, which typically resolve with appropriate anti-inflammatory therapy. The aim of this work is to report a case of uveitis in a patient on ipilimumab and nivolumab for the treatment of metastatic melanoma, as well as the response to therapy with difluprednate.

Keywords:
DifluprednateDifluprednatoImmune checkpoint inhibitorsInhibidores de puntos de control inmunitarioIpilimumabNivolumabUveitisUveítis

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