Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms Underlying the Impact of Feed-to-Gain Ratio Differences on Nutrient Metabolism in Simmental and Simmental × Hereford Crossbred Cattle Fed a Low-Energy Diet.

Animals : an open access journal from MDPI·2026
Same author

Deep learning for subtype classification of inner ear malformations on temporal bone HRCT: Development and multicenter validation.

European journal of radiology·2026
Same author

Scalable synthesis of highly crystalline 2D bimetallic MOFs on GO as electrode materials for alkaline zinc batteries.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Incremental diagnostic value of microstructural time-dependent diffusion MRI in differentiating PCNSL from glioblastoma over conventional MRI.

Magnetic resonance imaging·2026
Same author

Novel Insight into the Therapeutic Targets for Spinal Degenerative Diseases Gained by a Post-Genome-Wide Association Study.

International journal of medical sciences·2026
Same author

Metabolic profiling reveals circadian rhythms and lifestyle-associated changes.

Science China. Life sciences·2026

Related Experiment Video

Updated: Jan 16, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.2K

Characterization of brain microstructural abnormalities in spasmodic dysphonia using diffusion kurtosis imaging.

Fuzhuang Jiang1, Shizhen Zou2, Chunjie Wang1

  • 1Department of Radiology, The 6 th Medical Center, Chinese PLA General Hospital, Beijing, China.

Scientific Reports
|September 29, 2025
PubMed
Summary

Spasmodic dysphonia (SD) patients show brain microstructural changes in motor and auditory regions. Diffusion kurtosis imaging revealed correlations between these changes and clinical symptoms, suggesting a potential pathophysiologic basis for SD.

Keywords:
Diffusion kurtosis imagingMagnetic resonance imagingNeuroimagingSpasmodic dysphoniaVoice assessment

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.9K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.9K

Related Experiment Videos

Last Updated: Jan 16, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.2K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

26.9K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.9K

Area of Science:

  • Neuroimaging
  • Diffusion Tensor Imaging
  • Spasmodic Dysphonia Research

Background:

  • Spasmodic dysphonia (SD) is a voice disorder of unknown etiology.
  • Understanding the underlying neurobiology is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate brain microstructural alterations in SD patients using diffusion kurtosis imaging (DKI).
  • To explore correlations between diffusion metrics and clinical symptoms in SD.

Main Methods:

  • Diffusion kurtosis imaging (DKI) with b-values of 0, 1000, and 2000 s/mm² was performed on 20 SD patients and 20 healthy controls.
  • Analysis included kurtosis fractional anisotropy (FA), mean diffusion (MD), and mean kurtosis (MK).
  • Correlation analysis assessed the relationship between FA, MD, and clinical measures (jitter, grade, asthenia).

Main Results:

  • SD patients exhibited significantly reduced FA and increased MD in both white matter (WM) and gray matter (GM) compared to controls.
  • Mean kurtosis (MK) showed broader distribution changes than MD.
  • In WM, FA and MD were inversely correlated with jitter values.
  • FA and MD negatively correlated with disease grade, and frontal FA negatively correlated with asthenia.

Conclusions:

  • SD patients display microstructural changes in brain regions associated with motor control and auditory processing.
  • WM diffusion metric alterations correlate with SD clinical symptoms.
  • These brain changes may disrupt the central control of vocalization, potentially explaining the pathophysiology of SD.