Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Search research articles

Home
A Randomized, Controlled, Double-blinded Trial On The Effects Of Acellular Dermal Matrices On The Functional Assessment And Qualitative Satisfaction Of Split-thickness Skin Grafts.

Home
A Randomized, Controlled, Double-blinded Trial On The Effects Of Acellular Dermal Matrices On The Functional Assessment And Qualitative Satisfaction Of Split-thickness Skin Grafts.

Related Experiment Video

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

A randomized, controlled, double-blinded trial on the effects of acellular dermal matrices on the functional

Chae Rim Lee¹, Woo Shik Jeong², Young Chul Suh³

¹Department of Plastic and Reconstructive Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Scientific Reports

|September 29, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Keywords:

Acellular dermal matrix Defect Reconstructive surgery Skin graft

More Related Videos

Anterior Capsular Reconstruction with Human Dermal Allograft for Irreparable Subscapularis Tears

Anterior Capsular Reconstruction with Human Dermal Allograft for Irreparable Subscapularis Tears

Published on: May 9, 2025

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Related Experiment Videos

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation

Published on: March 4, 2016

Anterior Capsular Reconstruction with Human Dermal Allograft for Irreparable Subscapularis Tears

Anterior Capsular Reconstruction with Human Dermal Allograft for Irreparable Subscapularis Tears

Published on: May 9, 2025

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Acellular dermal matrix (ADM) combined with split-thickness skin grafts (STSGs) improves skin graft elasticity and reduces water loss and redness. Surgeons were more satisfied with ADM, but patient satisfaction showed no significant difference.

Area of Science:

Regenerative Medicine
Dermatology
Plastic Surgery

Background:

Acellular dermal matrix (ADM) is utilized in skin grafting to enhance graft take and scarring.
Functional outcomes of ADM in skin reconstruction require quantitative assessment.

Purpose of the Study:

To quantitatively evaluate the functional outcomes of acellular dermal matrix (ADM) combined with split-thickness skin grafts (STSGs) for full-thickness skin defects.
To compare elasticity, humidification, transepidermal water loss (TEWL), pigmentation, and erythema between ADM-augmented grafts and STSG-only grafts.

Main Methods:

A randomized controlled, double-blinded superiority study involving 54 patients with full-thickness skin defects.
Patients were randomized to receive either STSG with ADM or STSG alone.

Functional measurements and patient/surgeon satisfaction surveys were conducted at 6 months post-surgery.

Main Results:

ADM combined with STSGs demonstrated significantly greater elasticity, lower TEWL, and reduced erythema compared to STSG-only.
No significant differences were observed in humidification or pigmentation between the groups.
Surgeons reported higher satisfaction with the ADM group, while patient satisfaction was comparable.

Conclusions:

Co-grafting ADM with STSG in full-thickness wounds promotes favorable healing outcomes, specifically improving elasticity, TEWL, and erythema.
ADM augmentation offers enhanced functional results and higher surgeon satisfaction in skin reconstruction.
Further research may explore long-term patient-reported outcomes and cost-effectiveness.