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Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
Published on: March 26, 2015
Internal brace augmentation in ACL reconstruction increases structural strength and stiffness: a biomechanical study
Siqi Chen1, Junyuan Wang1, Junhua You2
1Department of Orthopedics, Joint Surgery and Sports Medicine, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
None:
This study was to compare the biomechanical outcomes of three ACL graft tibial fixations. Biomechanical testing was performed on 36 fresh porcine tibias and flexor profundus tendon divided into three groups: interference screw group (n = 12), internal brace group (n = 12) and combined group (n = 12). The samples underwent cyclic loading at 1 Hz at 50-250 N for 1000 cycles, following by load-to-failure testing (200 mm/min). The cyclic displacement, stiffness and ultimate failure loads were compared between the techniques. No sample failed during cyclic load test. The mean periodic displacement of the combined group (1.97 ± 0.32 mm)was significantly lower than both the internal brace group (2.85 ± 0.43 mm; p < 0.05) and interference screw group (2.48 ± 0.31 mm; p<0.05), but there was no significant difference between two fixation alone groups. The mean failure load of combined fixation (821.71 ± 78.39 N) was higher than that with interference screw (631.97 ± 109.96 N; p < 0.01) or internal brace (566.04 ± 57.68 N; P < 0.01) fixation alone. The combined group showed greater pullout stiffness (217.79 ± 36.66 N/mm) than both the interference screw (151.69 ± 30.28 N/mm; p < 0.01) and internal brace (162.94 ± 35.42 N/mm; p < 0.01) groups. Through biomechanical analysis, this study has demonstrated the feasibility of the soft tissue grafts fixed with internal brace and interference screw and its superiority in terms of higher ultimate failure load and stiffness compared to those fixed alone for anterior cruciate ligament reconstruction. The findings from this study have significant implications for enhancing ACL reconstruction surgery.
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